The motherboard is an ESD sensitive component and should be handled with care. iFixit recommends using a anti-static bracelet whenever handling components of this nature to avoid damage.

Grip the motherboard on both edges toward the top of the device.

Do not lift the motherboard all the way out in this step; the ribbon cable on the underside needs to be disconnected first.

Lift the motherboard up and away from the display, taking care not to put too much stress on the daughterboard ribbon cable.